Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders.

Neuronal glucose transporter (GLUT) isoform 3 deficiency in null heterozygous mice led to abnormal spatial learning and working memory but normal acquisition and retrieval during contextual conditioning, abnormal cognitive flexibility with intact gross motor ability, electroencephalographic seizures, perturbed social behavior with reduced vocalization and stereotypies at low frequency. This phenotypic expression is unique as it combines the neurobehavioral with the epileptiform characteristics of autism spectrum disorders. This clinical presentation occurred despite metabolic adaptations consisting of an increase in microvascular/glial GLUT1, neuronal GLUT8 and monocarboxylate transporter isoform 2 concentrations, with minimal to no change in brain glucose uptake but an increase in lactate uptake. Neuron-specific glucose deficiency has a negative impact on neurodevelopment interfering with functional competence. This is the first description of GLUT3 deficiency that forms a possible novel genetic mechanism for pervasive developmental disorders, such as the neuropsychiatric autism spectrum disorders, requiring further investigation in humans

Vertical variation of optical properties of mixed Asian dust/pollution plumes according to pathway of air mass transport over East Asia

© Author(s) 2015. This is an Open Access article made available under the terms of the Creative Commons Attribution License 3.0 https://creativecommons.org/licenses/by/3.0/We use five years (2009-2013) of multiwavelength Raman lidar measurements at Gwangju, South Korea (35.10° N, 126.53° E) for the identification of changes of optical properties of East Asian dust depending on its transport path over China. Profiles of backscatter and extinction coefficients, lidar ratios, and backscatter-related Ångström exponents (wavelength pair 355/532 nm) were measured at Gwangju. Linear particle depolarization ratios were used to identify East Asian dust layers. We used backward trajectory modeling to identify the pathway and the vertical position of dust-laden air masses over China during long-range transport. Most cases of Asian dust events can be described by the emission of dust in desert areas and subsequent transport over highly polluted regions of China. The Asian dust plumes could be categorized into two classes according to the height above ground at which these plumes were transported: (case I) the dust layers passed over China at high altitude levels (> 3 km) until arrival over Gwangju, and (case II) the Asian dust layers were transported near the surface and within the lower troposphere (< 3 km) over industrialized areas before they arrived over Gwangju. We find that the optical characteristics of these mixed Asian dust layers over Gwangju differ depending on their vertical position above ground over China and the change of height above ground during transport. The mean linear particle depolarization ratio was 0.21 ± 0.06 (at 532 nm), the mean lidar ratios were 52 ± 7 sr at 355 nm and 53 ± 8 sr at 532 nm, and the mean Ångström exponent was 0.74 ± 0.31 for case I. In contrast, plumes transported at lower altitudes (case II) showed low depolarization ratios (0.13 ± 0.04 at 532 nm), and higher lidar ratio (63 ± 9 sr at 355 nm and 62 ± 8 sr at 532 nm) and Ångström exponents (0.98 ± 0.51). These numbers show that the optical characteristics of mixed Asian plumes are more similar to optical characteristics of urban pollution. We find a decrease of the linear depolarization ratio of the mixed dust/pollution plume depending on transport time if the pollution layer traveled over China at low heights, i.e., below approximately 3 km above ground. In contrast, we do not find such a trend if the dust plumes traveled at heights above 3 km over China. We need a longer time series of lidar measurements in order to determine in a quantitative way the change of optical properties of dust with transport time.Peer reviewedFinal Published versio

Hawking Radiation of Black p-Branes from Gravitational Anomaly

We investigate the Hawking radiation of black $p$-branes of superstring theories using the method of anomaly cancelation, specially, we use the method of [S. Iso, H. Umetsu and F. Wilczek, {\sl Phys. Rev. Lett.} {\bf 96}, 151302 (2006); {\sl Phys. Rev. D} {\bf 74}, 044017 (2006)]. The metrics of black $p$-branes are spherically symmetric, but not the Schwarzschild type. In order to simplify the calculation, we first make a coordinate transformation to transform the metric to the Schwarzschild type. Then we calculate its energy-momentum flux from the method of anomaly cancelation of the above mentioned references. The obtained energy-momentum flux is equal to a black body radiation, the thermodynamic temperature of the radiation is equal to its Hawking temperature. And we find that the results are not changed for the original non-Schwarzschild type spherically symmetric metric.Comment: 19 pages Latex, some mistakes correcte

Dynamical evolution of the mass function and radial profile of the Galactic globular cluster system

Evolution of the mass function (MF) and radial distribution (RD) of the Galactic globular cluster (GC) system is calculated using an advanced and a realistic Fokker-Planck (FP) model that considers dynamical friction, disc/bulge shocks and eccentric cluster orbits. We perform hundreds of FP calculations with different initial cluster conditions, and then search a wide-parameter space for the best-fitting initial GC MF and RD that evolves into the observed present-day Galactic GC MF and RD. By allowing both MF and RD of the initial GC system to vary, which is attempted for the first time in the present Letter, we find that our best-fitting models have a higher peak mass for a lognormal initial MF and a higher cut-off mass for a power-law initial MF than previous estimates, but our initial total masses in GCs, M_{T,i} = 1.5-1.8x10^8 Msun, are comparable to previous results. Significant findings include that our best-fitting lognormal MF shifts downward by 0.35 dex during the period of 13 Gyr, and that our power-law initial MF models well-fit the observed MF and RD only when the initial MF is truncated at >~10^5 Msun. We also find that our results are insensitive to the initial distribution of orbit eccentricity and inclination, but are rather sensitive to the initial concentration of the clusters and to how the initial tidal radius is defined. If the clusters are assumed to be formed at the apocentre while filling the tidal radius there, M_{T,i} can be as high as 6.9x10^8 Msun, which amounts to ~75 per cent of the current mass in the stellar halo.Comment: To appear in May 2008 issue of MNRAS, 386, L6

On the shape of spectra for non-self-adjoint periodic Schr\"odinger operators

The spectra of the Schr\"odinger operators with periodic potentials are studied. When the potential is real and periodic, the spectrum consists of at most countably many line segments (energy bands) on the real line, while when the potential is complex and periodic, the spectrum consists of at most countably many analytic arcs in the complex plane. In some recent papers, such operators with complex $\mathcal{PT}$-symmetric periodic potentials are studied. In particular, the authors argued that some energy bands would appear and disappear under perturbations. Here, we show that appearance and disappearance of such energy bands imply existence of nonreal spectra. This is a consequence of a more general result, describing the local shape of the spectrum.Comment: 5 pages, 2 figure

Do Naked Singularities Form?

A naked singularity is formed by the collapse of a Sine-Gordon soliton in 1+1 dimensional dilaton gravity with a negative cosmological constant. We examine the quantum stress tensor resulting from the formation of the singularity. Consistent boundary conditions require that the incoming soliton is accompanied by a flux of incoming radiation across past null infinity, but neglecting the back reaction of the spacetime leads to the absurd conclusion that the total energy entering the system by the time the observer is able to receive information from the singularity is infinite. We conclude that the back reaction must prevent the formation of the naked singularity.Comment: 7 pages (21 Kb), PHYZZX. Revised version to appear in Class. & Quant. Grav. Letts. A discussion of the consistency of the Sine-Gordon model is include

Parity-violating asymmetry in γd→n⃗p\gamma d \to \vec{n}p with a pionless effective theory

Nuclear parity violation is studied with polarized neutrons in the photodisintegration of the deuteron at low energies. A pionless effective field theory with di-baryon fields is used for the investigation. Hadronic weak interactions are treated by parity-violating di-baryon-nucleon-nucleon vertices, which have undetermined coupling contants. A parity-violating asymmetry in the process is calculated for the incident photon energy up to 30 MeV. If experimental data for the parity-violating asymmetry become available in the future, we will be able to determine the unknown coupling contants in the parity-violating vertices.Comment: 4 pages. A contribution to APFB2011, August 22-26, 2011, Seoul, Kore